GLP-1 receptor agonists are a class of medications used to treat type 2 diabetes. They work by mimicking the action of a hormone called GLP-1, which helps to regulate blood sugar levels. In the UK, there are currently six GLP-1 receptor agonists available in the UK, all of which are self-administered by subcutaneous injection.
Recommended Dosages
The recommended doses for each GLP-1 receptor agonist vary. It's essential to follow your doctor's instructions carefully and not to change your dose without their guidance.
- Exenatide:
- Standard-release: 5 micrograms twice daily, increased if necessary to 10 micrograms twice daily.
- Modified-release: 2 mg once weekly.
- Liraglutide: 0.6 mg once daily, increased if necessary to 1.2 mg or 1.8 mg once daily.
- Lixisenatide: 10 micrograms once daily for 14 days, then increased to 20 micrograms once daily.
- Dulaglutide: 0.75 mg once weekly as monotherapy; 1.5 mg once weekly as add-on therapy.
- Semaglutide: 0.25 mg once weekly for 4 weeks, then 0.5 mg once weekly, then increased to 1 mg once weekly if needed.
- Tirzepatide: 2.5 mg once weekly for 4 weeks, then 5 mg once weekly, then increased if necessary up to 15 mg once weekly.
Contraindications and Cautions
GLP-1 receptor agonists are not suitable for everyone. They should not be used by people with certain conditions, such as ketoacidosis, pancreatitis, or severe renal impairment.
Additionally, they should be used with caution in people with a history of pancreatitis, renal impairment, hepatic impairment, or severe heart failure.
Adverse Effects
Like all medications, GLP-1 receptor agonists can cause side effects. The most common side effects are gastrointestinal, such as nausea, vomiting, and diarrhoea. Other possible side effects include headache, dizziness, and fatigue.
In rare cases, GLP-1 receptor agonists can cause acute pancreatitis. If you experience severe upper abdominal pain, nausea, and/or vomiting, seek urgent medical advice.
Key Takeaways
GLP-1 receptor agonists are an effective treatment option for type 2 diabetes. However, it's important to be aware of the potential risks and side effects before starting treatment. If you have any questions or concerns, talk to your doctor.
Disclaimer:
This blog post is intended for informational purposes only and should not be considered a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before starting any new treatment or making any changes to your existing treatment plan.
Remember, managing type 2 diabetes requires a comprehensive approach that includes medication, lifestyle changes, and regular monitoring. By working closely with your healthcare team, you can successfully manage your condition and improve your overall health and well-being.
